Репозиторий Российская Офтальмология Онлайн по протоколу OAI-PMH
Офтальмологические конференции и симпозиумы
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23-я Всероссийская научно-практическая конференция с международным участием
Современные технологии лечения витреоретинальной патологии 2026
22-я Всероссийская научно-практическая конференция с международным участием
Современные технологии лечения витреоретинальной патологии 2025
23-я Всероссийская научно-практическая конференция с международным участием
Современные технологии лечения витреоретинальной патологии 2026
| Реферат RUS | Реферат ENG | Литература | Полный текст |
| УДК: | DOI: https://doi.org/10.25276/2312-4911-2025-3-138-144 |
Балашова Л.М., Богомолова Е.А., Колоколова Л.А., Лесовой C.В., Симирский В.Н., Маркитантова Ю.В.
Исследование ключевых компонентов сигнальных путей в клетках ретинального пигментного эпителия, координирующих регенерацию и патологии сетчатки
1. George, S.M., Lu, F., Rao, M., et al. The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems. Prog. Retin. Eye Res. 2021;85:100969.
2. Chiba Ch., Mitashov V. Cellular and molecular events in the adult newt retinal regeneration. Review Book «Strategies for Retinal Tissue Repair and Regeneration in Vertebrates: from Fish to Human». Ed. Ch. Chiba. Research Singpost. 2007.
3. Grigoryan E.N., Markitantova Y.V. Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela. Biomedicines. 2016;4(4):pii: E28, 1–18.
4. Fuhrmann S., Zou Ch. J., Levine E.M. Retinal pigment epithelium development, plasticity, and tissue homeostasis. Exp. Eye Res. 2014;4:141–150.
5. Bhutto I., Lutty G. Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex. Mol. Aspects Med. 2012;33:295–317.
6. Markitantova Y., Simirskii V. Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes. Int. J. Mol. Sci. 2020;21(5):1602.
7. Andreazzoli M. Molecular regulation of vertebrate retina cell fate. Birth Defects Research. 2009;87:284–295.
8. Martins B., Pires M., Ambrosio A.F., et al. Contribution of extracellular vesicles for the pathogenesis of retinal diseases: Shedding light on blood-retinal barrier dysfunction. J. Biomed. Sci. 2024;31:48.
9. Whitcup S.M., Nussenblatt R.B., Lightman S.L., Hollander D.A. Inflammation in retinal disease. Int. J. Inflam. 2013:724648.
10. Markitantova Y., Fokin A., Boguslavsky D., Simirskii V., Kulikov A. Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl. Int. J. Mol. Sci. 2023;24:16940. https://doi.org/10.3390/ ijms242316940
11. Müller F., Rohrer H., Vogel-Höpker A. Bone morphogenetic proteins specify the retinal pigment epithelium in the chick embryo. Development. 2007;134(19):3483–3493. doi: 10.1242/dev.02884
12. Li H., Yang S., et al. Inhibitory Effect of Bone Morphogenetic Protein 4 in Retinal Pigment EpithelialMesenchymal Transition. Sci. Rep. 2016;6:32182. doi: 10.1038/srep32182
13. Zhu D.H., Wu J., Spee C., et al. BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration BMP4 might inhibit TGF-β-mediated EMT in RPE cells. J. Biol. Chem. 2009;284(14):9529–9539. doi: 10.1074/jbc. M809393200
14. Darwish N.H.E., Hussein K.A., Elmasry K., et al. Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy. Cells. 2023;12:1279. doi. org/10.3390/ cells12091279
15. Liu J., Wilson S., Reh T. BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev. Biol. 2003;256:34–48.
16. Thompson A., Berry M., Logan A., Ahmed Z. Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration. Invest. Ophthalmol. Vis. Sci. 2019;60:1748– 1759. doi.org/10.1167/iovs.18-26449
17. Ueki Y., Wilken M.S., Cox K.E., et al. A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation. Development. 2015;142:533–543. doi: 10.1242/dev.118745
18. Lenkowski J.R., Qin Z., Sifuentes C.J., et al. Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia. 2013;61:1687–1697.
19. Firsova N.V., Markitantova Yu.V., Smirnova Yu.A., et al. Analysis of TGFbeta2 expression in human eye tissues in prenatal development. Dev. Biol. 2011;38:10–16.
20. Sugino I.K., Sun Q., Springer C., et al. Two bioactive molecular weight fractions of a conditioned medium enhance RPE cell survival on age-related macular degeneration and aged Bruch’s membrane. Transl. Vis. Sci. Technol. 2016;5:8.
21. Braunger B.M., Pielmeier S., Demmer C., et al. TGF-β signaling protects retinal neurons from programmed cell death during the development of the mammalian eye. J. Neurosci. 2013;33:14246– 14258.
22. Higashijima F., Hasegawa M., Yoshimoto T., et al. Molecular mechanisms of TGFb-mediated EMT of retinal pigment epithelium in subretinal fibrosis of age-related macular degeneration. Front. Ophthalmol. 2023;2:1060087. doi: 10.3389/fopht.2022.1060087
23. Markitantova Yu.V., Avdonin P.P., Grigoryan E.N. FGF2 signaling pathway components in tissues of the posterior eye sector in the adult newt Pleurodeles waltl. Dev. Biol. 2014;41:297–305.
24. Bharti K., Nguyen M.T.T, Skuntz S., et al. The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res. 2006;19(5):380–394. doi: 10.1111/j.1600-0749.2006.00318.x
25. Avdonin P.P., Markitantova Yu.V., Zinovieva R.D., Mitashov V.I. Expression of regulatory genes Px6, Otx2, Six3, and FGF2 during newt retina regeneration. Dev. Biol. 2008;35:355–361.
26. Yamamoto C., Ogata N., Yi X., Takahashi K. Immunolocalization of basic fibroblast growth factor during wound repair in rat retina after laser photocoagulation. Graefes Arch. Clin. Exp. Ophthalmol. 1996;234(11):695–702. doi: 10.1007/BF00292356
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5 Июня 2026 г.
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