Antioxidant activity of some pharmaceuticals used in ophthalmology

    

    Abstract

    Antioxidant activity of some pharmaceuticals used in ophthalmology

    M.R. Guseva, O.S. Komarov, N.M. Galkina

    Pirogov Russian National Research Medical University, Russian Federatin, Moscow

    Purpose. Identification of antioxidant activity (AOA) in known pharmaceutical drugs used for eye treatment and comparative evaluation of their antioxidant properties.

    Material and methods. The experimental part of the work was carried out on a model system using a suspension of yolk lipoproteins. This model has several advantages: availability, ease of isolation, storage stability, and reproducibility. The clinical part of work consisted in inclusion of these drugs in the treatment course of patients with inflammatory eye diseases.

    Results. In this experiment, a high AOA of several drugs was found. As a result, it may be possible to expand their spectrum of applications in treatment of ophthalmic pathology.

    Conclusions. In several cases, the antioxidant activity of previously known and widely used in ophthalmological practice pharmaceutical drugs was found. The discovery of new properties in known drugs makes it possible to expand the spectrum of their application, considering the identified antioxidant properties. The inclusion of drugs with an antioxidant effect in the treatment course for patients with inflammatory eye diseases can reduce the duration of treatment and increase its effectiveness.

    Keywords: antioxidants; medicines; initiators of oxidation, lipoproteins

    

    For quoting: Guseva M.R., Komarov O.S., Galkina N.M. Antioxidant activity of some pharmaceuticals used in ophthalmology. Rossiyskaya detskaya oftalmologiya. 2022;3: 36–41. https://doi.org/10.25276/2307-6658-2022-3-36-41

    

    Corresponding author: Oleg S. Komarov, komolsam@mail.ru