Expression of interferon α and interferon γ in the lachrymal fluid of patients with dry eye syndrome with blepharitis and conjunctivitis

    Abstract

    Expression of interferon α and interferon γ in the lachrymal fluid of patients with dry eye syndrome with blepharitis and conjunctivitis

    Konovalova N.V.

    SI «The Filatov Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine» (Odessa) Ukraine

    

    We showed that the level of interferon’s in the lachrymal fluid of patients with dry eye syndrome with blepharitis and conjunctivitis. Had made (24.460±8.179) and (27,550±8,289) pg/ml for interferon α and interferon γ with minimum and maximum values – (14.4-39.3) pg/ml and (14.3-41.4) pg/ml, respectively, which was higher than those in normal individuals. The contents of cytokines under investigation in blepharitis and conjunctivitis are significantly higher in the lachrymal fluid than in the blood plasma (2.2 and 1.8 respectively), which is evidence of dominance of their expression locally. There was revealed paired positive correlation between baseline interferon α in the lachrymal fluid and plasma of patients with dry eye syndrome with blepharitis and conjunctivitis (n=20, r=0.76, p<0.05), which is evidence of the possibility of the characteristics of the pathological process in the eye by the change of its expression in the peripheral blood. The data analysis of changes in the level of interferon expression in the lachrymal fluid of patients with after treatment showed that the content of interferon α correlates with dry eye syndrome with blepharitis and conjunctivitis the corresponding data in the blood of patients before therapeutic interventions (n=20, r=0.74, p<0.05). We founded an association between the level of interferon γ in the lachrymal fluid of patients of dry eye syndrome with blepharitis and conjunctivitis before and after the treatment (n=20, r=0.84, p<0.05).

    Key words: dry eye syndrome, blepharitis, conjunctivitis, lachrymal fluid, interferon α, interferon γ.