Репозиторий OAI—PMH
Репозиторий Российская Офтальмология Онлайн по протоколу OAI-PMH
Конференции
Офтальмологические конференции и симпозиумы
Видео
Видео докладов
Реферат RUS | Реферат ENG | Литература | Полный текст |
УДК: | 617.741-004.1-089 DOI: https://doi.org/10.25276/0235-4160-2022-3-8-12 |
A.A. Shpak , A.B. Guekht , T.A. Druzhkova , A.A. Troshina , N.V. Gulyaeva
Glial cell line-derived neurotrophic factor in patients with age-related cataract

НМИЦ «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава РФ
Научно-практический психоневрологический центр имени З.П. Соловьева Департамента здравоохранения города Москвы
Институт высшей нервной деятельности и нейрофизиологии РАН
Abstract
Glial cell line-derived neurotrophic factor in patients with age-related cataract
A.A. Shpak , A.B. Guekht , T.A. Druzhkova , A.A. Troshina , N.V. Gulyaeva
Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation
Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russian Federation
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian Federation
Purpose. To study the content of glial cell line-derived neurotrophic factor (GDNF) in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract.
Material and methods. The content of GDNF in the LF, AH and BS was studied in 47 patients (47 eyes) with age-related cataract. Collection of stimulated LF was performed with a pipette on the day preceding surgery; the AH and BS were sampled during the phacoemulsification of a cataract. The concentration of GDNF was measured using an enzyme immunoassay.
Results. The concentration of GDNF in the AH was 88.9±46.9 (2.0–212.5) pg/ml, in the BS – 201.1±44.6 (103.2–287.2) pg/ml, in the LF – 343.6±133.7 (172.8– 683.0) pg/ml. The levels of GDNF in the studied biological fluids did not show any significant correlations with each other.
Conclusion. In patients with age-related cataract, the level of GDNF in the AH was relatively low: the concentration of GDNF in the AH was more than 2 times lower than in the BS and almost 4 times lower than in the LF. No significant correlations were found between the concentrations of GDNF in LF, AH and BS.
Key words: glial cell line-derived neurotrophic factor, lacrimal fluid, aqueous humor, blood serum, age-related cataract
For quoting: Shpak A.A., Guekht A.B., Druzhkova T.A., Troshina A.A., Gulyaeva N.V. Glial cell line-derived neurotrophic factor in patients with age-related cataract. Fyodorov Journal of Ophthalmic Surgery. 2022;3: 8–12. https://doi.org/10.25276/0235-4160-2022-3-8-12
Corresponding author: Anna A. Troshina, anna.troshina221B@yandex.ru
Страница источника: 8
Каталог
Продукции
Организации
Офтальмологические клиники, производители и поставщики оборудования
Издания
Периодические издания
Партнеры
Проекта Российская Офтальмология Онлайн