Study of hemodynamics and microcirculation of the eye in pregnant women   with gestational diabetes mellitus

    Abstract

    Study of hemodynamics and microcirculation of the eye in pregnant women   with gestational diabetes mellitus

    N.V. Pomytkina, E.L. Sorokin

    The S. Fyodorov Eye Microsurger y Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russia
Far-Eastern State Medical University, Khabarovsk, Russia

    Purpose. Analysis of the state of hemodynamics and microcirculation of the eye in pregnant women with gestational diabetes mellitus (GDM).

    Material and methods. 248 pregnant women with GDM and 60 healthy women with physiological gestation, and depending on the timing (trimester), GSD1, GSD2, and GSD3 were identified. The following were examined: subfoveal choroidal thickness, optical coherence tomography angiography (OCTA) parameters, color Doppler mapping (CDM) in the central retinal artery (CRA) and posterior short ciliary arteries (PSCA).

    Results. There were no significant differences in choroidal thickness and OCTA parameters between pregnant women with GDM and healthy pregnant women, and in subgroups with different periods of GDM onset. In patients with GDM, a decrease in blood flow velocity indices in the CRA and PSCA was found, with the exception of the end-diastolic velocity in the PSCA, as well as the resistance index in the PSCA, compared to the control group. This was associated with vasodilation in the ophthalmic artery system at the level of large vessels, while maintaining stable perfusion at the level of the microcirculatory bed due to autoregulation mechanisms.

    Conclusion. No significant differences in subfoveal choroidal thickness and OCTA indices were found in the third trimester in pregnant women with GDM and with physiological gestation, including at different stages of its onset. In this trimester, a decrease in most blood flow velocity indices in the CAS and PCCAA, as well as the resistance index in the latter, was noted, compared to the control. At the same time, at different stages of GDM manifestation, there were no significant differences in hemodynamic parameters in the PCCAA and CAS in the third trimester.

    Key words: gestational diabetes, OCT angiography, ocular microcirculation, color Doppler mapping

    For quoting: Pomytkina N.V., Sorokin E.L. Study of hemodynamics and microcirculation of the eye in pregnant women with gestational diabetes mellitus. Point of view. East – West. 2024;11(4): 1–17.

    DOI: https://doi.org/10.25276/2410-1257-2024-4-11-17

    Corresponding author: Natalia V. Pomytkina, naukakhvmntk@mail.ru