Local chronic aseptic inflammation in the pathogenesis of primary openangle glaucoma (POAG), the role of imbalance of biologically active molecules

    Abstract

    Trunov A.N., Konenkov V.I., Orlov N.B., Eremina A.V., Bratko G.V., Chernykh V.V.

    Local chronic aseptic inflammation in the pathogenesis of primary openangle glaucoma (POAG), the role of imbalance of biologically active molecules

    The academician S.N. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk Branch, Novosibirsk

    Scientific Research Institute of Clinical and Experimental Lymphology - a branch of Federal Research Center of the Institute of Cytology and Genetics, SB RAS, Novosibirsk

    Federal Research Center for Fundamental and Translational Medicine, SB RAS, Novosibirsk

    Purpose. Purpose: to study the content of pro-inflammatory cytokines and matrix metalloproteinases in the intraocular fluid in patients with advanced stage of primary open-angle glaucoma.

    Material and methods. 50 patients were examined with a verified diagnosis of the advanced stage of poag. the control group consisted of 30 patients with a diagnosis of uncomplicated cataract. the concentration of the determined biologically active molecules was carried out by the method of flow fluorimetry on a two-beam laser analyzer -Bio-plex 200, Bio-rad, USA.

    Results. A statistically significant increase in the concentrations of Il-6, 8, 12, 17, mIp-1β matrix metalloproteinase-2 was found in the intraocular fluid of patients with poag.

    Conclusion. The data obtained indicate the significance of the local inflammatory process, as well as disturbances in the structure of the extracellular matrix in the mechanisms of poag development.

    Keywords: primary open-angle glaucoma, intraocular fluid, cytokines, matrix metalloproteinases