The Results of the Use of Autologous Platelet-Rich Plasma as Part of a Comprehensive Treatment Regimen for Uveitis Associated With Systemic Diseases and Accompanied by Macular Edema

    Abstract

    The Results of the Use of Autologous Platelet-Rich Plasma as Part of a Comprehensive Treatment Regimen for Uveitis Associated With Systemic Diseases and Accompanied by Macular Edema

    N.S. Arbenyeva, V.I. Bratko, G.V. Bratko, A.N. Trunov, O.V. Poveshchenko, V.V. Chernykh

    S. Fyodorov Eye Microsurgery Federal State Institution of the Ministry of Health of the Russian Federation, Novosibirsk Branch
Federal Research Center for Fundamental and Translational Medicine, Novosibirsk
Research Institute of Clinical and Experimental Lymphology, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk

    Purpose. To evaluate the clinical-ophthalmic effectiveness of using of autologous platelet-rich plasma as part of a comprehensive treatment regimen for uveitis associated with systemic diseases and accompanied by macular edema.

    Material and methods. The study included 120 people (176 eyes) from 18 to 50 years old with uveitis associated with systemic diseases, accompanied by macular edema: 46 men, 74 women. Patients were divided into 2 groups: the main group consisted of patients receiving anti-inflammatory treatment and autologous platelet-rich plasma application; control group consisted of patients receiving anti-inflammatory treatment. All patients underwent a comprehensive ophthalmological examination.

    Results. It was found that autologous platelet-rich plasma application during anti-inflammatory treatment for patients with uveitis associated with systemic diseases and accompanied by macular edema improves best-corrected visual acuity, statistically significant decrease in retinal thickness in fovea and increase in retinal photosensitivity relative to the data obtained in the control group.

    Conclusion. The use of autologous platelet-rich plasma in combination with anti-inflammatory treatment decreases incidence of relapse of uveitis associated with systemic diseases, contributes to reducing macular edema and improving functional performance.

    Key words: uveitis, macular edema, anti-inflammatory treatment, autologous platelet-rich plasma.